Uttwiler Spätlauber Apple Stem Cells

PhytoCellTec Swiss Apple Stem Cells

http://www.evolle.com

	The European Award Winning Best Active Ingredient PhytoCellTecTM Swiss Apple Stem Cells from Switzerland Swiss Apple Stem cells to protect skin stem cells A Swiss Apple Variety with Incredible Properties Uttwiler Spätlauber is a variety of a Swiss apple that derives from a seedling planted in the middle of the 18th century. It was very famous for its excellent storability without shriveling. Today apple cultivars are selected to maximize crop yield and sweet flavor. Thus Uttwiler Spätlauber with its acid taste is now disappearing.  Uttwiller Spätlauber apples are rich in phytonutrients, proteins and long-living cells. This particular composition leads to incredible storability and longevity properties.  Plant Stem Cells to Protect Skin Stem Cells Plant cells are totipotent, meaning that every cell has the ability to regenerate new organs (leave, flower, seeds...) or even the whole plant. Besides, all plant cells can dedifferentiate and become a stem cell.   All stem cells, independently of their origin contain specific epigenetic factors whose function is to maintain the self renewal capacity of stem cells. Claims with PhytoCellTecTM Malus Domestica
	Protects longevity of skin stem cells
	Delay senescence of essential cells
	Combats chronological aging
	Preserves the youthful look and vitality of your skin
	Real Rejuvenation products for face and body
	First plant stem cell active ingredient on market
	Breakthrough in anti-aging
	Award winner (BSB innovation prize for the best active ingredient 2008)
	In clinical tests, the apple's stem cells appeared to be protecting human stem cells.  Like a youth tonic, they were nourishing and stimulating them, defending them from UV radiation (like a natural SPF booster), even delaying their aging and death.  USA Vogue November 2009

My Quest For Infos on APPLE STEM CELLS - Article fr www.swissinfo.ch

Online Article from Swiss News and Informations Platform of Switzerland Nov 28, 2009

http://www.swissinfo.ch/eng/swiss_news/A_Swiss_apple_a_day_keeps_wrinkles_at_bay.html?cid=7668056

A Swiss apple a day keeps wrinkles at bay

The Uttwiler Spätlauber is little known and has been dying out 

A rare Swiss apple is being hailed in the cosmetic and fashion world as an exciting anti-ageing breakthrough – even Michelle Obama is rumoured to be a fan.

Used in creams and serums, stem cells from the Uttwiler Spätlauber apple are said to protect skin cell regeneration and so delay the onset of wrinkles. The discovery was made by a Swiss company.

The November edition of the United States Vogue magazine went as far as to call the variety "the super-apple", and asked if the tree could be "the new fountain of youth".

The Uttwiler Spätlauber, which was first recorded in the 18th century, comes from canton Thurgau, in northern Switzerland.

It is well known for its excellent storability; it can stay fresh looking for up to four months after being harvested, long after other varieties have become wrinkled.

However, it has not been widely cultivated of late because of its sour taste and the number of trees have dwindled.

Amazing longevity

Having collected some samples, Swiss researchers set to work and found that the answer mostly lay in the amazing longevity of the apple's stem cells.

Humans have skin stem cells, which replenish and maintain the balance of cells within the skin tissue and regenerate tissue which has been damaged.

But with age, the number of skin stem cells decreases and their ability to repair the skin becomes less efficient. The result is – with added environmental damage like UV rays - a loss of skin vitality, and inevitably, wrinkles.

Mibelle Biochemistry, which developed the apple ingredient, found that the apple stem cells were protecting the skin stem cells from ageing.

"We thought there must be something in those apples which give them their long shelf life," said Beata Hurst, marketing and sales manager at Mibelle Biochemistry.

"We could show that the apple stem cells have a positive influence on the vitality of the skin stem cells, they made them more efficient and they can live longer," Hurst told swissinfo.ch.

The firm, which is a subsidiary of the big Swiss retailer Migros, used a novel technology to replicate the apple cells called PhytoCellTec™.

Michelle Obama is said to use an apple a day to keep wrinkles at bay (Keystone)

Michelle Obama

The apple ingredient has been snapped up by cosmetics companies in Europe, Asia, and the United States, including Lancôme and Chantecaille.

According to the Vogue article, style icon and presidential wife Michelle Obama buys a serum using the apple made by Clark's Botanicals, costing $355 (SFr361).

The Uttwiller Spätlauber was found in one of the collections belonging to ProSpecieRara, a foundation aiming to preserve traditional breeds of animals and plants in Switzerland.

ProSpecieRara director Béla Bartha told swissinfo.ch that there were only 20 Uttwiller Spätlauber trees left at present, which he said was not surprising. Some fruit varieties have between one and five trees left.

Saving rare species

Overall, ProSpecieRara has managed to preserve 1,800 varieties on 8,000 trees during its 25 years in operation, through collecting samples, growing them and then distributing them to people willing to look after them.

The Uttwiller Spätlauber is found on Hansrudolf Schweizer's farm in Neukirch in Thurgau.

Bartha said that ProSpecieRara operated an open source strategy, giving people access to the resources. It also ensures that this biodiversity is grown in the field, rather than stored gene banks, giving it a visibility.

The apple is not the only rare variety success story: a cross of two old potato breeds resulted in a blue potato which is now made into potato crisps, which are sold in supermarkets.

Bartha said that ProSpecieRara never dreamed when it put the Uttwiller Spätlauber into Schweizer's orchard that it would be successfully used in cosmetic production. This was, he said, not the aim.

But the case has served to highlight a cornerstone of the foundation's work, he pointed out, namely showing that old varieties house a genetic pool which could be harvested for new uses.

"We have undiscovered treasures in these collections," said Bartha.

Isobel Leybold-Johnson, swissinfo.ch

My Quest For Infos on APPLE STEM CELLS - Article fr www.telegraph.co.uk

Swiss apple is key to Michelle Obama's youthful looks

http://www.telegraph.co.uk/news/worldnews/northamerica/usa/michelle-obama/6684364/Swiss-apple-is-key-to-Michelle-Obamas-youthful-looks.html

The secret of Michelle Obama's youthful looks may be a rare Swiss apple with an exceptionally long shelf-life. 

By Alexandra Williams in Geneva

Published: 7:00AM GMT 30 Nov 2009

Michelle Obama, the First Lady of the United States of America

According to the US edition of Vogue, the First Lady buys a £215 serum which uses an extract from the stem cells of the Uttwiler Spätlauber apple.

The variety stays fresh for up to four months after being harvested, long after other varieties have become wrinkled.

Used in creams and serums, stem cells from the fruit are said to stimulate human skin stem cells, thereby protecting skin cell regeneration and delaying the onset of wrinkles.

It is being hailed in the cosmetic world as an exciting anti-ageing breakthrough and has been snapped up by around 100 beauty firms in Europe, Asia, and the United States, including Lancôme and Chantecaille.

Vogue has dubbed it "the super apple" and asked if the tree could be "the new fountain of youth".

Despite its long shelf-life, the apple has not been considered desirable until now because of its tart taste. Consequently the number of trees has rapidly dwindled.

The variety, first recorded in the mid-18th century, comes from northern Switzerland. If the tree's bark or the skin of an unpicked fruit is punctured it heals. And once picked, an Uttwiler Spätlauber apple lasts months longer than its shrivelled cousins.

Swiss scientists at Mibelle Biochemistry, which is a subsidiary of the big Swiss retailer Migros, decided to investigate whether the miracle component could be harnessed to stop the ageing process in people.

They found the key to the apple's longevity lay chiefly in its unusually resilient stem cells.

In clinical tests the apple's stem cells appeared to be protecting human stem cells. They nourished and stimulated them and defended them against UV radiation.

They made a cream containing a two per cent Uttwiler Spätlauber extract and applied it twice daily to the "crow's feet" area under the eyes of 20 participants. Wrinkle depth was reduced by an average of 15 per cent after four weeks.

"We thought there must be something in those apples which gives them their long shelf life," said Beata Hurst, marketing and sales manager at Mibelle Biochemistry.

"We could show that the apple stem cells have a positive influence on the vitality of the skin stem cells. They made them more efficient and they can live longer."

At present there are only 20 Uttwiller Spätlauber trees in Switzerland. They belong to ProSpecieRara, a foundation aiming to preserve traditional breeds of animals and plants in Switzerland.

The organisation has managed to preserve 1,800 varieties on 8,000 trees during its 25 years in operation, through collecting samples, growing them and then distributing them to people willing to look after them.

Bela Bartha, foundation director, said: "We have undiscovered treasures in these collections."

My Quest For Infos on APPLE STEM CELLS - Le Magazine Nov 2008

LE Magazine November 2008

Apple Stem Cells Offer Hope For Aging and Damaged Skin By Gary Goldfaden, MD

As we age, the reduced turnover of our cells means we can lose control over how our skin ages. Epidermal stem cells needed to create healthy new skin are significantly reduced and function less efficiently. A discovery based on promising plant stem cell research may allow you to regain control. Scientists have found that a novel extract derived from the stem cells of a rare apple tree cultivated for its extraordinary longevity shows tremendous ability to rejuvenate aging skin. By stimulating aging skin stem cells, this plant extract has been shown to lessen the appearance of unsightly wrinkles. Clinical trials show that this unique formulation increases the longevity of skin cells, resulting in skin that has a more youthful and radiant appearance. Stem Cells Cells in our bodies are programmed for specific functions. A skin cell, a brain cell, and a liver cell all contain the same DNA, or set of genes. However, each cell’s fate is determined by a set of epigenetic (able to change gene expression patterns) signals that come from inside it and from the surrounding cells as well. These signals are like command tags attached to the DNA that switch certain genes on or off. This selective coding creates all of the different kinds of cells in our bodies, which are collectively known as differentiated (specialized) cells. Although differentiated cells vary widely in purpose and appearance, they all have one thing in common: they all come with a built-in operational limit. After so many divisions, they lose their ability to divide and must be replaced. This is where stem cells come in. Your body also produces other cells that contain no specific programming. These stem cells are “blank,” so your body can essentially “format” them any way it pleases. Two universal aspects shared by this type of cell are: (1) the ability to replenish itself through a process of self-renewal and (2) the capacity to produce a differentiated cell. In animals and humans, two basic kinds of stem cells exist: embryonic and adult stem cells. Embryonic stem cells have the power to change into any differentiated cell type found anywhere in your body. Adult stem cells, on the other hand, are generally more limited. They can only evolve into the specific type of cell found in the tissue where they are located. The primary function of these adult stem cells is maintenance and repair. But certain adult stem cells found in nature retain the unlimited developmental potential that embryonic stem cells possess. These cells have become the main focus for an exciting new wave ofregenerative medicine (repairing damaged or diseased tissues and organs using advanced techniques like stem cell therapy and tissue engineering). The Role of Stem Cells in the Skin The basal (innermost) layer of the skin’s epidermis comprises two basic types of cells: (1) the slowly dividing epidermal stem cells (that represent about 2-7% of the basal cell population) and (2) their rapidly dividing offspring that supply new cells to replace those that are lost or dying.1-3 The slow self-renewal process of epidermal stem cells, however, creates a problem. Because each epidermal stem cell only lasts for a certain number of divisions, and because each division runs the risk of lethal DNA mutation, the epidermal stem cell population can become depleted. When this happens, lost or dying skin cells begin to outnumber their replacements and the skin’s health and appearance start to decline. So what can be done? Scientists turned to plants for the answer. Planting a Seed of Hope Plants also have stem cells. Like humans, plant stem cells depend on epigenetic control and signals from surrounding cells for their development. Unlike humans, however, each plant-derived adult stem cell possesses the ability to generate a whole new plant.4 Scientists have found a way to harness the power of plant stem cells by growing plant tissues in culture. The technique is a relatively simple one. First, viable tissue is obtained from a source plant. This material is called an explant. Next, a small cut is made in the explant. New cells form on the surface of this cut in an attempt to heal the wound. This colorless mass of cells is called a callus. The slowly dividing cells of a callus are undifferentiated cells that lack the characteristics of normal plant cells. They are essentially unprogrammed and full of potential. With this technology, it is theoretically possible to propagate any plant cell in a liquid culture, opening up a whole new realm of possibilities. This fact started scientists thinking—what would happen if an extract of genetically long-lived plant stem cell tissue was applied to human skin? Comparing Apples to Apples Today, apples are cultivated primarily to enhance their appearance and flavor. But before the rise of refrigeration, an apple’s ability to stay fresh for a long time was its most sought-after characteristic. For this reason, a special variety of apple was cultivated in the middle of the 18th century that could be stored for a greatly extended period of time. In essence, it was the genetically modified, longer-living stem cells of this tannin-rich variety of apple, called the Uttwiler Spätlauber apple, which were responsible for its unique storage longevity. In a certain isolated area of rural Switzerland, a few of these hardy apple trees still survive today. Scientists obtained an explant from the leaf of one of these trees to produce a special anti-aging stem cell extract. The Amazing Results In order to test the theory that this unique plant extract would produce anti-aging effects, scientists at Mibelle Biochemistry first obtained human stem cells from the blood of an umbilical cord. Their first in-house study on cell viability showed that, at a concentration of only 0.1%, an extract of Uttwiler Spätlauber stem cells stimulated the proliferation of human stem cells by an astounding 80%! 5 In a second experiment, these scientists irradiated the umbilical cord blood stem cells with UV light. Nearly 50% of the stem cells cultured in growth medium alone died, but the cells grown in the culture containing the special apple extract showed only a small decrease in the number of living cells.5 Another in vitro experiment conducted by the scientists involved fibroblast cells. These are the most common of all cells in the connective tissue of the skin. They manufacture the collagen, glycosaminoglycans, reticular and elastic fibers, and glycoproteins that make up the extracellular matrix (connective tissues providing support to cells). Fibroblasts not only help provide a structural framework for the skin, they also play a critical role in wound healing. In their experiment, the scientists treated fibroblast cells with hydrogen peroxide for two hours until the cells began to show classic signs of aging. In scientific terms, this means that several genes essential for cell proliferation and growth were significantly down-regulated. However, after incubating these cells for 144 hours in a 2% Uttwiler Spätlauber extract, this down-regulation of genes was effectively neutralized, and in some cases, it was actually reversed! In addition, the scientists noted that the expression of an important antioxidant enzyme called heme oxigenase 1 was also stimulated.5 Finally, the scientists conducted a human study to determine the anti-wrinkle effectiveness of a special cream containing a 2% Uttwiler Spätlauber extract along with lecithin liposomes. This patent-pending cream (called PhytoCellTec™ Malus Domestica) was applied twice daily to the crow’s feet area of 20 participants. Wrinkle depth was reduced by an average of 8% after just two weeks, and by 15% after four weeks—thus reducing the signs of aging!5 WHAT YOU NEED TO KNOW: APPLE STEM CELLS OFFER HOPE FOR AGING AND DAMAGED SKIN Scientists are conducting intensive research on stem cells, which show tremendous potential to repair damaged tissues and organs. Stem cells are capable of self-renewal and can transform themselves into differentiated cells. Epidermal stem cells are crucial to replenish the skin cells that are lost due to continual shedding. When epidermal stem cells are depleted, the number of lost or dying skin cells outpaces the production of new cells, threatening the skin’s health and appearance. Like humans, plants also have stem cells. Scientists are keenly interested in a stem cell extract from the Uttwiler Spätlauber apple tree, whose fruit demonstrates an exceptionally long shelf-life. This extract, termed PhytoCellTec™ Malus Domestica, has been shown to stimulate human stem cell proliferation, protect stem cells against ultraviolet light-induced death, and mitigate aging-related alterations in gene expression. A human study showed that topical application of PhytoCellTec™ Malus Domestica reduced the depth of crow’s feet wrinkles after only two weeks. Chondrus crispus (red seaweed) extract, hyaluronic acid, and an antioxidant tea blend complement the effects of PhytoCellTec™ Malus Domestica to help promote radiant, youthful skin. Revitalize Your Skin A potent concentration of this PhytoCellTec™ Malus Domestica is now available to help preserve and protect your vital skin stem cells. This special apple extract complements other ingredients provided in a new topical formula. One is a special extract of Chondrus crispus, a red seaweed found only in the cold waters off the Atlantic coast. With its abundance of mineral salts, trace elements, proteins, and vitamins, this extract is an excellent emollient with soothing, anti-inflammatory properties.6 Other anti-aging ingredients are hyaluronic acid (noted for its outstanding moisturizing ability)7 and a concentrated antioxidant tea blend, which helps fight the free radicals that contribute to skin aging.8,9 Combined, these ingredients comprise an innovative topical formulation that protects and preserves the youthful look and vitality of your skin in ways never before possible. Just a tiny bit applied to your face, neck, and décolleté area twice daily can help revitalize the tone, texture, and appearance of aging skin. Gary Goldfaden, MD, a clinical dermatologist and lifetime member of the American Academy of Dermatology, is founder of Academy Dermatology in Hollywood, FL, and COSMESIS Skin Care. He is also a member of the Life Extension Scientific Advisory Board. If you have any questions on the scientific content of this article, please call a Life Extension Health Advisor at 1-800-226-2370.

References

1. Barthel R, Aberdam D. Epidermal stem cells. J Eur Acad Dermatol Venereol. 2005 Jul;19(4):405-13. 2. Aberdam D. Epidermal stem cell fate: what can we learn from embryonic stem cells? Cell Tissue Res. 2008 Jan;331(1):103-7. 3. Blanpain C, Fuchs E. Epidermal stem cells of the skin. Annu Rev Cell Dev Biol. 2006;22:339-73. 4. Byrne ME, Kidner CA, Martienssen RA. Plant stem cells: divergent pathways and common themes in shoots and roots. Curr Opin Genet Dev. 2003 Oct;13(5):551-7. 5. Schmid D, Schurch P, Belser E, Zülli F. Plant Stem Extract for Cell Longevity of Skin and Hair. SOFW Journal. 2008;134(5):30-5. 6. Herve C, de Franco PO, Groisillier A, Tonon T, Boyen C. New members of the glutathione transferase family discovered in red and brown algae. Biochem J. 2008 Jun 15;412(3):535-44. 7. Price RD, Berry MG, Navsaria HA. Hyaluronic acid: the scientific and clinical evidence. J Plast Reconstr Aesthet Surg. 2007;60(10):1110-9. 8. Ojo OO, Ladeji O, Nadro MS. Studies of the antioxidative effects of green and black tea (Camellia sinensis) extracts in rats. J Med Food. 2007 Jun;10(2):345-9. 9. McKay DL, Blumberg JB. A review of the bioactivity of South African herbal teas: rooibos (Aspalathus linearis) and honeybush (Cyclopia intermedia). Phytother Res. 2007 Jan;21(1):1-16.

Day 1 : Monday 4 Oct 2010

Monday 4.10.10 :))) ~ Day 1 : My first Go Geous intake. Nice looking box. Striking red box with 30 sachets of Go Geous, divided into 4 compartments...mmm...brilliant I thought, 30 sachets divided into 4 compartments so like 4 weeks of supply, so you know when you miss a day etc.


Opened the sachet and its in powder form, stir into half glass of room temperature water..its dissolved immediately into berries looking juice, drank it and yes :))) it tastes like a berries juice. Very easy and taste good too ! Not too bad I thought ...good start :)))


Love it !


Ciao

Blogging my Go Geous experience :)))

My informal introduction to Go Geous was in August 2010, when my cousin Azwan upload a testimonial of her younger sister onto FB then another testimonial of a person whom I know. One day during puasa month bumped into the guy, he's outlook positively good, we chatted and I asked him about Go Geous.

Raya was a wonderful time with family and close friends. We cousins got together ....mmm....i must say Azwan is looking good, very nice complexion :)))

We cousins met again, ...they shared their experience about Go Geous, in their own words a health supplement to enhance cells rejuvenation, improve the firmness, youthfulness of skin....from an Apple Stem Cells.

So ooookay.....what did I do .....like millions of other people trying to find infos, I googled !

....and I am also taking the supplement now....wanna know more :))) come visit my blog for more :)))

Ciao  XOXO